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PreventAutism.org
Category 3
Laboratory Animal Studies
16
Numerous studies in laboratory animals from multiple laboratories indicate that early life exposure to APAP causes long term changes in brain function.
Laboratory mice and rats show long-term behavioral changes when given acetaminophen at a very young age
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Early life exposure to APAP has a greater long-term impact on male laboratory animals than female laboratory animals. ASD is more common in males than in females.
The effects of acetaminophen and related drugs hurt social function in male brains more than in female brains
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Prenatal exposure of laboratory rats to APAP causes problems with the processing of sound and with olfactory function. Impairment of olfactory function and some degree of auditory dysfunction (reviewed by Graeca and Kulesza) are associated with ASD.
Acetaminophen causes death of cortical neurons in adult laboratory rats at concentrations lower than it causes liver failure
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APAP causes apoptosis-mediated death of cortical neurons in laboratory rats , and cortical neurons may be involved in the pathology of ASD.
Normal doses of acetaminophen are toxic in cats because they are deficient in 'the glucuronidation pathway" of metabolism. Newborn babies are also deficient in this metabolic pathway
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