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Category 3

Animal Studies
Animals are biologically very similar to humans, they are susceptible to many of the same health problems as humans, and their shorter life cycles enable us to study them throughout their whole life span.

The lines of evidence related to animal studies make up 16.7% of the total evidence.
08
Long-term behavioral changes occur when mouse and rat pups are exposed to acetaminophen
Laboratory mice and rats show long-term behavioral changes when given acetaminophen at a very young age
09
Acetaminophen exposure in early life negatively affects social function in male brains more than in female brains
The effects of acetaminophen and related drugs hurt social function in male brains more than in female brains
10
Acetaminophen kills nerve cells in the brain in adult lab animals
Acetaminophen causes death of cortical neurons in adult laboratory rats at concentrations lower than it causes liver failure
11
Acetaminophen is toxic to cats because they are missing a critical "pathway", same as babies
Normal doses of acetaminophen are toxic in cats because they are deficient in 'the glucuronidation pathway" of metabolism. Newborn babies are also deficient in this metabolic pathway
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